vep
Pack: ensembl · Endpoint: https://gateway.pipeworx.io/ensembl/mcp
Variant Effect Predictor — region in “chrom:start-end:strand” form.
Parameters
| Name | Type | Required | Description |
|---|---|---|---|
species | string | yes | |
region | string | yes | e.g. “9:22125504-22125504:1” |
allele | string | yes | e.g. “C” |
Example call
curl -X POST https://gateway.pipeworx.io/ensembl/mcp \
-H 'Content-Type: application/json' \
-d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"vep","arguments":{}}}'Response shape
Full JSON Schema
{
"type": "array",
"description": "Variant Effect Predictor results",
"items": {
"type": "object",
"properties": {
"variant_id": {
"type": "string",
"description": "Variant identifier"
},
"allele_string": {
"type": "string",
"description": "Reference/alternate alleles"
},
"seq_region_name": {
"type": "string",
"description": "Chromosome"
},
"start": {
"type": "integer",
"description": "Start position"
},
"end": {
"type": "integer",
"description": "End position"
},
"strand": {
"type": "integer",
"description": "Strand"
},
"transcript_consequences": {
"type": "array",
"description": "Predicted consequences",
"items": {
"type": "object",
"properties": {
"consequence_terms": {
"type": "array",
"description": "Consequence term list",
"items": {
"type": "string"
}
},
"transcript_id": {
"type": "string",
"description": "Transcript ID"
},
"gene_id": {
"type": "string",
"description": "Gene ID"
},
"biotype": {
"type": "string",
"description": "Transcript biotype"
},
"impact": {
"type": "string",
"description": "Predicted impact"
},
"hgvsc": {
"type": "string",
"description": "HGVS cDNA notation"
},
"hgvsp": {
"type": "string",
"description": "HGVS protein notation"
}
}
}
}
}
}
}Connect
Add this to your MCP client config, or use one-click install buttons:
{
"mcpServers": {
"ensembl": {
"url": "https://gateway.pipeworx.io/ensembl/mcp"
}
}
}See Getting Started for client-specific install steps.