Reactome

liveBiologyScience

Reactome — open biological pathway database. Keyless.

5tools
0msauth
free tier50 calls/day

Tools

pathwayrequired: id

Pathway record.

Parameters
NameTypeDescription
idreqstring—
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participantsrequired: id

Pathway participants.

Parameters
NameTypeDescription
idreqstring—
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pathways_for_entityrequired: entity_id

Pathways containing an entity (by resource + id).

Parameters
NameTypeDescription
resourceoptstring—
entity_idreqstring—
speciesoptstring—
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orthologous_eventsrequired: id, species

Orthologous events in another species.

Parameters
NameTypeDescription
idreqstring—
speciesreqstring—
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Test with curl

The gateway speaks JSON-RPC 2.0 over HTTP POST. You can test any pack directly from the terminal.

List available tools
bash
curl -X POST https://gateway.pipeworx.io/reactome/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/list"}'
Call a tool
bash
curl -X POST https://gateway.pipeworx.io/reactome/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":2,"method":"tools/call","params":{"name":"search","arguments":{"query": "hello"}}}'

Use with the SDK

Install @pipeworx/sdk to call tools from any TypeScript/Node project.

TypeScript
import { Pipeworx } from '@pipeworx/sdk';
const px = new Pipeworx();
const result = await px.call("search", {"query":"example"});
ask_pipeworx
// Or ask in plain English:
const answer = await px.ask("reactome — open biological pathway database");