gnomAD

live BioGenomics

Broad Institute gnomAD — genome aggregation, population allele frequencies, variant annotations (GraphQL). Keyless.

5 tools
0ms auth
free tier 50 calls/day

Tools

variant required: variant_id

Variant by id or rsid.

Parameters
Name Type Description
variant_id req string —
dataset opt string —
▶ Try it
gene required: gene_symbol_or_id

Gene + variants.

Parameters
Name Type Description
gene_symbol_or_id req string —
dataset opt string —
▶ Try it
region required: chrom, start, stop

Variants in a region.

Parameters
Name Type Description
chrom req string —
start req number —
stop req number —
dataset opt string —
▶ Try it
transcript required: transcript_id

Transcript + variants.

Parameters
Name Type Description
transcript_id req string —
dataset opt string —
▶ Try it

Test with curl

The gateway speaks JSON-RPC 2.0 over HTTP POST. You can test any pack directly from the terminal.

List available tools
bash 
curl -X POST https://gateway.pipeworx.io/gnomad/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/list"}'
Call a tool
bash 
curl -X POST https://gateway.pipeworx.io/gnomad/mcp \
  -H "Content-Type: application/json" \
  -d '{"jsonrpc":"2.0","id":2,"method":"tools/call","params":{"name":"variant","arguments":{"variant_id": "example"}}}'

Use with the SDK

Install @pipeworx/sdk to call tools from any TypeScript/Node project.

TypeScript 
import { Pipeworx } from '@pipeworx/sdk';
const px = new Pipeworx();
const result = await px.call("variant", {"variant_id":"example"});
ask_pipeworx 
// Or ask in plain English:
const answer = await px.ask("broad institute gnomad — genome aggregation, population allele frequencies, variant annotations (graphql)");