`civic_gene_variants`

Pack: civic · Connect: https://pipeworx.io/mcp (see Connect below for a single-pack URL)

No MCP client? Call it directly: GET https://gateway.pipeworx.io/v1/tools/civic_gene_variants for the schema, then POST the same URL with its arguments for the data.

Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associated diseases and therapies. AUTHORITATIVE for “which variants of this gene are clinically actionable”. Pass the gene symbol.

Parameters

Name	Type	Required	Description
`gene`	string	yes	Gene symbol (e.g. “BRAF”)
`variant_name`	string	no	Optional substring filter on the variant name (e.g. “V600”)
`limit`	number	no	Max variants to return, 1-100 (default 25)

Example call

Arguments

{
  "gene": "BRAF",
  "variant_name": "V600",
  "limit": 5
}

curl

curl -X POST https://gateway.pipeworx.io/civic/mcp \
  -H 'Content-Type: application/json' \
  -d '{"jsonrpc":"2.0","id":1,"method":"tools/call","params":{"name":"civic_gene_variants","arguments":{"gene":"BRAF","variant_name":"V600","limit":5}}}'

TypeScript (@pipeworx/sdk)

import { Pipeworx } from '@pipeworx/sdk';
const pipeworx = new Pipeworx();

const result = await pipeworx.call('civic_gene_variants', {
  "gene": "BRAF",
  "variant_name": "V600",
  "limit": 5
});

Connect

Add this to your MCP client config — every tool in the catalog, including this one — or use one-click install buttons:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://pipeworx.io/mcp"
    }
  }
}

Connect to just the civic pack

{
  "mcpServers": {
    "civic": {
      "url": "https://gateway.pipeworx.io/civic/mcp"
    }
  }
}

See Getting Started for client-specific install steps.

civic_gene_variants